What are the characteristic histology of leiomyoma?

What are the characteristic histology of leiomyoma?

Uterine leiomyomas are noncancerous monoclonal neoplasms arising from uterine smooth muscle cells and fibroblasts [7,8]. They contain a large amount of extracellular matrix (including collagen, proteoglycan, fibronectin) and are surrounded by a thin pseudocapsule of areolar tissue and compressed muscle fibers.

What is the meaning of leiomyoma?

(LY-oh-my-OH-muh) A benign smooth muscle tumor, usually in the uterus or gastrointestinal tract. Also called fibroid.

Is leiomyoma a tumor?

Leiomyomas are benign tumors arising from smooth muscle, most commonly seen in uterine myometrium, gastrointestinal tract, skin and lower extremities of middle-aged women.

What is the cell of origin of leiomyoma?

Leiomyomas are benign tumors of monoclonal origin which arise from the smooth muscle of the uterus[2][8]. Leiomyomas are primarily composed of extracellular matrix and cells with a low mitotic index [7][8]. They are encapsulated with a pseudocapsule composed of areolar tissue [8].

Are Leiomyomas painful?

Pilar leiomyomas are the most common of the cutaneous types and the lesions are often multiple and painful. A burning or sharp, stabbing pain may occur spontaneously or can be provoked by touch/pressure and cold temperature.

What are the types of fibroids?

There are three major types of uterine fibroids. Intramural fibroids grow within the muscular uterine wall. Submucosal fibroids bulge into the uterine cavity. Subserosal fibroids project to the outside of the uterus.

Why is leiomyoma painful?

The cause of the pain is unclear and it is thought to be a result of either smooth muscle contractions or dense nerve fibers bundled within the tumor. Angioleiomyomas are only painful in about half of cases and usually are found on the lower legs, while genital leiomyomas are typically solitary and asymptomatic.

How are Leiomyomas removed?

In a myomectomy, your surgeon removes the fibroids, leaving the uterus in place. If the fibroids are few in number, you and your doctor may opt for a laparoscopic or robotic procedure, which uses slender instruments inserted through small incisions in your abdomen to remove the fibroids from your uterus.

What is the most common type of leiomyoma?

Intramural leiomyomas arise within the wall of the uterus. They are the most common type of leiomyomas, and can be associated with infertility, miscarriage, fetal malpresentation, and preterm birth.

What kind of nodules are found in leiomyoma?

Dissecting leiomyoma: Nodules of smooth muscle cells dissecting the myometrium; occasionally hydropic changes and intravenous extension can be seen Called cotyledonoid leiomyoma if extends outside the uterus Diffuse leiomyomatosis: Diffuse, poorly circumscribed, innumerable tumor nodules in the myometrium No atypia and tumor cell necrosis

What is the histopathology of uterine leiomyomas?

The histopathology of uterine leiomyomas following treatment with gonadotropin-releasing hormone analogues Gonadotropin-releasing hormone analogues (GnRH agonists) cause pituitary desensitization by downregulation of GnRH receptors, decrease gonadal steroid production, and reduce uterine volume in women with leiomyomas.

Is there a difference between leiomyomas and leiomyosarcomas?

Although necrosis of leiomyomas is associated with GnRH agonist treatment, the lack of significant pleomorphism or mitotic activity distinguishes these altered leiomyomas from leiomyosarcomas. Publication types Comparative Study MeSH terms

How many mitoses are there in a leiomyoma?

Mitoses are rare (4 mitoses/10 high power fields). Tumor borders are well circumscribed. By immunohistochemistry the tumor cells are positive for desmin, h-caldesmon, ER and PR.