Is plectin a plakin?

Is plectin a plakin?

Plectin is a prototypical plakin that tethers intermediate filaments to membrane-associated complexes. Other plakins, such as bullous pemphigoid antigen 1 and microtubule and actin cross-linking factor 1, are likely to have similar extended plakin domains.

What is the function of plectin?

In addition plectin links the cytoskeleton to junctions found in the plasma membrane that structurally connect different cells. By holding these different networks together plectin plays an important role in maintaining the mechanical integrity and viscoelastic properties of tissues.

Where is plectin found?

Plectin has been found to be expressed in virtually all mammalian tissues and cell types. It decorates different types of IFs, shows codistribution with their plasma membrane anchoring structures, and colocalizes with microfilaments (actin structures), primarily in peripheral areas of cells.

Is Nebulin a contractile protein?

Nebulin is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. It is a very large protein (600–900 kDa) and binds as many as 200 actin monomers….Nebulin.

Available structures
PDB Human UniProt search: PDBe RCSB
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What are Hemidesmosomes made of?

Hemidesmosomes consist of membrane-spanning proteins tetraspanin (CD151), type XVII collagen (BP180), and integrin α6β4 heterodimer, as well as cytoplasmic plakin family proteins BP230 and plectin (Litjens et al., 2006).

What is EB simplex?

Epidermolysis bullosa simplex is one of a group of genetic conditions called epidermolysis bullosa that cause the skin to be very fragile and to blister easily. Blisters and areas of skin loss (erosions) occur in response to minor injury or friction, such as rubbing or scratching.

What does nebulin do in muscle?

Thus, nebulin is critical for physiological force levels in skeletal muscle because it stiffens the thin filament, promotes thin filament activation, and enhances cross-bridge recruitment.

Are integrins hemidesmosomes?

Hemidesmosomes (HDs) are highly specialized integrin-mediated epithelial attachment structures that make cells firmly adhere to the extracellular matrix by establishing a link between the underlying basement membrane (BM) and the internal mechanical stress-resilient keratin intermediate filament (IF) network.

Can EB be detected in the womb?

Prenatal testing In some cases it’s possible to test an unborn baby for EB after the 11th week of pregnancy. Prenatal tests include amniocentesis and chorionic villus sampling.

Is EB contagious?

Unfortunately, there are several rare types that can cause significant pain and more severe disease. EB is not contagious, it is a genetic (inherited) skin condition. It cannot be caught by coming into contact with people who have it.